Cobalt complexes as antiviral and antibacterial agents pdf

One of the most promising classes of coiii complexes containing n. Two novel copper ii and cobalt ii complexes of anilinevanillin schiff base were synthesized, char acterized and examined for their antibacterial activity. One of the most promising classes of coiii complexes containing n, o. One of the most promising classes of coiii complexes containing n, o donor ligands is the. Cobalt is one of the important trace elements, which is regarded as an essential element for humans and is less toxic than nonessential metals23. Structure, antimicrobial activity, dna and albuminbinding, european journal of medicinal chemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Rare earth ions possess the properties of antibacterial 11, antitumor 12 and antivirus agents when co. One of the most promising classes of co iii complexes containing n, o donor ligands is the. The anticancer potential of cobalt complexes has been extensively studied over the last three decades, and much time has been devoted to understanding their mechanisms of action. By far the most common ligand type used to stabilize the cobaltiii ion in aqueous solution is the chelating n,o donor ligand. Syntheses, characterization, and antibacterial study of. Harnessing the properties of cobalt coordination complexes for biological application.

Introduction the scientific literature has described in detail the antiviral, antibacterial, antitumor and antifungal activities of coordination compounds of coii and coiii111. Ternary complexes containing an amino acid as a secondary ligand have significance as they are potential models for enzyme metal ion substrate complexes 10. Recently, complexes of cobalt iii have been found to have antibacterial and antiviral activities eddie et al. Spectroscopic studies suggested the distorted octahedral structure for all complexes. May 26, 2010 by far the most common ligand type used to stabilize the cobalt iii ion in aqueous solution is the chelating n,o donor ligand. Here, we report our studies on the antiviral activity of two thiosemicarbazone metal complexes, biscitronellalthiosemicarbazonatonickelii and aquapyridoxalthiosemicarbazonatocopperii chloride monohydrate, against the retroviruses. The copper complexes of schiff bases have striking properties such as antibacterial, antifungal, antiviral, antiinflammatory, antitumor and cytotoxic activities, plant development controller, enzymatic activity and applications in pharmaceutical fields. Metalorganic compounds were reported to exhibit fungicidal, bactericidal, and antiviral activities its inhibitory activity was not significant, at high concentration it was more toxic to replicating cells than to stationary cell monolayers of vero cells.

A highly potent antibacterial agent targeting methicillinresistant staphylococcus aureus based on cobalt bis1,2dicarbollide alkoxy derivative. Synthesis, biological evaluation and corrosion inhibition. Transition metal complexes as drugs and chemotherapeutic agents by nicholas farrell the university of vermont, burlington, vermont, u. Pdf cobalt complexes as antiviral and antibacterial agents.

Antiretroviral activity of thiosemicarbazone metal complexes. Surprisingly, cobaltiii complexes derived from this ligand donor set have found application as antibacterial or antiviral agents. Other heavy metal cations such as hg and pb have antimicrobial activities, but can be. Oct 20, 2017 interaction of two mononuclear tetracoordinate complexes codmphenbr2 and codmpheni2 dmphen 2,9dimethyl1,10phenanthroline, which have been recently reported to behave as singlemolecule magnets smms in an applied external field, with calf thymus ct dna in solution was studied by spectral methods uvvis, fluorescence, and circular dichroism. Synthesis, characterization and antimicrobial activities of. There is a recent report of another kind of cobalt complex, based on coordination with pyridineamide ligands, that shows antibacterial activity mishra et al.

Complexes of curcumin with cobalt nanoparticles showed increased antibacterial activity against e. Knightcobalt complexes as antiviral and antibacterial agents. Nov 14, 20 read preparation and characterization of antibacterial cobalt exchanged natural zeolitepolyvinyl alcohol hydrogels, journal of solgel science and technology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Coiii complexes, deprotonation and reducion processes, antimicrobial activity. Synthesis, spectroscopic characterization and antimicrobial activity evaluation of new tridentate schiff bases and their coii complexes. Synthesis, structural, spectral characterization and dna. Synthesis of coii and criii salicylidenic schiff base complexes derived from thiourea as precursors for nanosized co3o4 and cr2o3 and their catalytic, antibacterial properties, journal of nanostructure in chemistry, 2017, pp. The antibacterial result was found comparable with the commercial drug gentamicin even at lower concentration of complexes. This indicates their usefulness as broad spectrum antibacterial agents.

However, no study reported attempts to form cobalt complexes with curcumin. Interaction of two mononuclear tetracoordinate complexes codmphenbr2 and codmpheni2 dmphen 2,9dimethyl1,10phenanthroline, which have been recently reported to behave as singlemolecule magnets smms in an applied external field, with calf thymus ct dna in solution was studied by spectral methods uvvis, fluorescence, and circular dichroism. Ferrocne compounds, metal complexes, ferrocenyl complexes, antimicrobial agents. Metalii coordination compounds of glycine and phenylalanine were synthesized and characterized using infrared and electronic spectroscopic, and magnetic susceptibility measurements.

Antibacterial, antifungal and in vitro antileukaemia activity of. Harnessing the properties of cobalt coordination complexes. Jan 15, 2008 antiviral properties of cobaltiii complexes. Review cobalt complexes as antiviral and antibacterial. Cobalt complexes as antiviral and antibacterial agents mendeley. Thus, the synthesized complexes may be considered as potential antibacterial agents after passing cytotoxicity testing. Pdf metal ion complexes are playing an increasing role in the development of antimicrobials. Advances in cobalt complexes as anticancer agents dalton. The transition metal complexes formed from schiff base is regarded as leading molecules in medicinal chemistry. Synthesis, structural investigation and biological.

In this process, schiff bases and metal nitrate were dissolved in ethanol separately. Metal complex or coordination compound is a structure consisting of a central metal atom, bonded to a. Schiff bases are the most widely used organic compounds. However, higher activities given by these cobalt complexes than those of copper, contrary to the antimicrobial potencies of their metals 4,3235, may indicate the influence of the proposed dinuclear structure.

Antimicrobial activity of cobaltii complexes with 2aminobenzimidazole derivatives sanja o. Synthesis of coii and criii salicylidenic schiff base. Systems in which the entire cobalt complex has bioactivity are generally used for antiviral, antifungal or antibacterial applications. We have investigated the potential antiviral activity of three cobaltiii compounds. Bioactive small molecules that elicit therapeutic action in vivo, such as nonsteroidal antiinflammatory drugs nsaids 1719, antibacterial agents 20,21, antiprotozoal agents 22,23, antifungal agents 24,25, and antihelmintic agents, have been attached to cobalt complexes to improve or alter their therapeutic efficacy.

The former role was firstly attrubuted to the fact that vitamin b12 cobalamin is substituted. Synthesis and characterization of cobaltiii and copper. Cobalt complexes are widely studied for their antiviral, antibacterial activities and as chaperones in prodrugs. However, only the cobalt iii complexes enjoy growing. Synthesis, structural investigation and biological application of new. Cobalt bisdicarbollide and its ammonium derivatives are effective antimicrobial and antibiofilm agents.

In the present work, we have designed and prepared schiff base and its metal complexes mc1mc4 and screened them for. The complexes performed well even against the gramnegative bacteria. Antibacterial agents can be used empirically, either knowing the pathogen or as a prophylactic treatment. Metal ion complexes are playing an increasing role in the development of antimicrobials. Read preparation and characterization of antibacterial cobaltexchanged natural zeolitepolyvinyl alcohol hydrogels, journal of solgel science and technology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Cetkovic1 cobaltii chloride reacts with 2aminobenzimidazole derivatives to give complexes of the formula col2cl2, where l2aminobenzimidazole, 1benzyl2aminobenzimida. Later on, domagk 1953 prepared an important chemotherapeutic agent sulfanilamide. The way to minimize problems caused by the metalbased drugs is to make complexes, which are similar to cisplatin, but contains a. Read cobaltii complexes with the antimicrobial drug enrofloxacin. Synthesis and antibacterial activity of cobaltii complex. Synthesis and characterization of cobaltiii and copperii. Andrew knight no static citation data no static citation data cite. Research article preparation and characterization of di.

Reports on antibacterial properties of cobalt complexes have demonstrated that. Design of hiv protease inhibitors based on inorganic. The aim of this study is to investigate the antiviral effects of cobaltiimorin complex. To investigate the applications of the synthesized complexes, in the next step, the complexes were screened for antibacterial activity against clinically important bacteria such as escherichia coli, staphylococcus aureus, and bacillus subtilis. Study of single and double chain surfactantcobalt iii complexes and their hydrophobicity, micelle formation, interaction with serum albumins and antibacterial activities. Antibacterial cobalt ii, copper ii, nickel ii and zinc ii complexes. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Sorry, we are unable to provide the full text but you may find it at the following locations. Synthesis, characterization and antimicrobial activity of cobalt metal complex against. Archived from the original pdf on 23 november 2011. Synthesis and antibacterial activity of cobaltii complex of. Synthesis and characterization of low oxidation state. Cobalt complexes as antiviral and antibacterial agents by eddie l. Schiff base complexes are also used as potent antiviral, antibacterial and antitumor agents 18.

The best results were achieved with complex iii and both thiourea complexes. Antiviral properties of cobaltiiicomplexes request pdf. Chelating agents and metal complexes as antiviral agents chelating agents metal. The interest on cobalt complexes in experimental cancer therapy research results from their role as systemic anticancer agents and their ability to redoxdependent targeting the tissue of solid tumours. Abstractmetal ion complexes are playing an increasing role in the development of antimicrobials. The most effective among these systems is the series of cobalt compounds known as the ctc series of cobalt complexes, which has been shown to possess antiinflammatory 4 and antiviral activity. Synthesis, physicochemical characterization and antimicrobial. Cobalt complexes as antiviral and antibacterial agents open. Oct 30, 2014 read cobaltii complexes with the antimicrobial drug enrofloxacin. Complexes iiii and mscnh224cl2 m pd, pt, and coen3cl3 were tested for in vitro antiviral activity against the acalifornia0709 h1n1pdm09 influenza virus. The criii and coii complexes showed good biological activity against all the tested bacteria. Synthesis, characterization and antibacterial properties. Synthesis, characterization and antibacterial activity of some 3d metal complexes of sulphadimidine.

In vitro bioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus ct dna were carried out by employing uvvis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. Preparation and characterization of antibacterial cobalt. In the present work, we have designed and prepared schiff base and its metal complexes. Of the three compounds investigated herein, coiiihex was the only cobalt complex that exhibited significant antiviral activity against sindbis virus in an in vitro model of viral replication. However, only the cobaltiii complexes enjoy growing. Synthesis, characterization and antimicrobial activities. This perspective catalogues the development of antiproliferative cobalt complexes, and provides an in depth analysis of their mode of action. Based on this, we report three new mixed ligand complexes of cobalt iiviz. Synthesis, characterization and antibacterial activity of.

Many antiviral drugs are designed to treat infections by retroviruses, including hiv. The activity of schiff base ligand is usually increased by complexation with the metal ion. Research article preparation and characterization of di, tri, and tetranuclear. Synthesis, characterization and antibacterial activity.

Antiviral properties of cobaltiiicomplexes sciencedirect. Biological activities of schiff bases and their complexes. Hexaammine cobalt iii chloride is a trivalent complex cation of coiii and amine that has previously been shown to act as an inhibitor of insulin secretion, radiosensitizing agent, and an. Synthesis, characterization and antibacterial properties of. Strongly bound metal complexes to antimicrobial agents are introduced as another possible way for synergistic activity of respective antimicrobial agents through elevation of the binding effect of them to the bacterial walls. Cobalt iii complexes of oxaazamacrocycles derived from. The structures and geometry of schiff base and complexe s were determined on the basis of elemental analysis h, c and n, h nmr, c nmr, ftir spectra, aas and magnetic susceptibility measurements. The complexes were tested for antimicrobial activity against bacillus subtilis, staphylococcus aureus, methicillin resistant staphylococcus aureus mrsa, escherichia coli. One of the most promising classes of coiii complexes containing n, o donor ligands is the ctc series of complexes 1 based on a chelating schiff base imd imidazole. Surprisingly, cobalt iii complexes derived from this ligand donor set have found application as antibacterial or antiviral agents. Antibacterial agent an overview sciencedirect topics.

Copper and cobalt complexes can cleave dna through an oxidative or hydrolytic mechanism. Mercury and silver salts as antibacterial agents mercury silver antibacterial activity of chelating agents and metal. Because of the preparative availability and diversity in the structure of central group, the transition metals are important in coordination chemistry. The effect of the free ligand and its metal complexes on the proliferation of hl60 cells. The antimicrobial study has shown that all the compounds are potential antibacterial agents against gramnegative bacterial strains and better antifungal agents with respect to standard drugs used. European journal of medicinal chemistry 2007, 4310, 21892196.

Thiosemicarbazones display a wide antimicrobial activity by targeting bacteria, fungi, and viruses. Antibacterial screening of the ligands as well as the complexes was carried. Cobalt complexes as antiviral and antibacterial agents core. Ferrocenyl complexes display various pharmacological intrests such as antibacterial and antifungal activities.

Syntheses, characterization, and antibacterial study of titanium complexes raj kaushal, 1. Preparation of zinc oxide nanomaterial using unsymmetrical. Cobalt complexes as antiviral and antibacterial agents mdpi. In spite of a large number of antibiotics and chemotherapeutics available for medical use, at the same time the emergence of old and new antibiotic resistance. Various properties of cobalt coordination complexes can theoretically be harnessed in the preparation of systems that. Antipathogenic activity of cuii complexes incorporating. Cobalt complexes as antiviral and antibacterial agents. Classification of antibacterial agents the antibacterial agents are classified in three categories. After sterilization, the medium was allowed to cool and 0. Structure iii was confirmed by xray diffraction cif file ccdc no. The scope of metal complexes in drug design indian drug. Review cobalt complexes as antiviral and antibacterial agents. They have been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, antiinflammatory, antiviral, and antipyretic properties. Given the presence of sindbis virus rna in the cytoplasm and the high efficiency with which the coiii cyclen complexes hydrolyze nucleic acids, we expected that they would inhibit viral replication.